{Reference Type}: Journal Article
{Author}: Turlo, J.; Gutkowska, B.; Herold, F.; Luczak, I.
{Year}: 2009
{Title}: Investigation of the Kinetics of Selenium Accumulation by Lentinula edodes (Berk.) Mycelial Culture by Use of Reversed-Phase High-Performance Liquid Chromatography with Fluorimetric Detection
{Tag}: 0
{Star}: 0
{Journal}: ACTA CHROMATOGRAPHICA
{Volume}: 21
{Issue}: 1
{Pages}: 1-11
{ISBN/ISSN}: 1233-2356
{Keywords}: IMMUNE CELL FUNCTIONS; BIOLOGICAL-MATERIALS; SUPPLEMENTATION; 2,3-DIAMINONAPHTHALENE; CANCER; WATER; LEM; Lentinula edodes; selenium analysis; RP HPLC
{Abstract}: We hypothesized that extracts from selenium (Se)-enriched Lentinula edodes mycelia would have higher anticancer and immunostimulating properties than the non-enriched extracts currently used to treat cancer. Previously, we demonstrated that submerged cultivated mycelia of L. edodes accumulated Se from the cultivation medium very efficiently, more so than yeast. The objective of this study was to investigate the kinetics of Se accumulation by L. edodes mycelial culture. The L. edodes mycelia were cultivated in medium enriched with 20 mu g mL(-1) Se in a 10-L jar fermenter. Each day, a 100-mL sample was taken from the fermenter and the concentration of Se in the dried mycelia, in the filtered medium, and in the wash water was determined by reversed-phase high-performance liquid chromatography (RP HPLC). We adapted a widely used fluorimetric method based on derivatization with 2,3-diaminonaphthalene for analysis of Se for RP HPLC. Se recovery was determined on the basis of the theoretical amount of Se in the cultivation medium. To detect volatile selenium compounds released from the fermenter, the concentration of Se in the ethanol and in the activated charcoal used in the washers and exhaust filters was determined. The time-course of the Se content of dry mycelial biomass and in filtered medium indicated that the most effective accumulation of Se occurred at the beginning of the trophophase (log phase of growth), between the second and fourth days of cultivation. The Se concentration in mycelia peaked on day 7 (3041 mu g g(-1)) and decreased thereafter in proportion to the increase in the concentration of Se in the ethanol and activated charcoal from the fermenter exhaust filters.
{Author Address}: Med Univ Warsaw, Dept Drug Technol, PL-02097 Warsaw, Poland; Med Univ Warsaw, Dept Drug Technol, PL-02097 Warsaw, Poland; Med Univ Warsaw, Dept Drug Technol, PL-02097 Warsaw, Poland; Med Univ Warsaw, Fac Pharm, PL-02097 Warsaw, Poland
{Database Provider}: Web of Science SCI
{Language}: English
{Country}: Poland; Poland

{Reference Type}: Journal Article
{Author}: Marinovic, B.; Jukic, I. L.; Lipozencic, J.
{Year}: 2012
{Title}: [Wounds in autoimmune bullous dermatoses and systemic connective tissue diseases]
{URL}: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=23193815&query_hl=1
{Tag}: 0
{Star}: 0
{Journal}: Acta Med Croatica
{Volume}: 66 Suppl 1
{Pages}: 13-7
{Date Displayed}: 2012 Oct
{Date}: 2012-10-01
{Type of Work}: English Abstract; Journal Article; Review
{Accession Number}: 23193815
{Keywords}: Autoimmune Diseases/*diagnosis; Connective Tissue Diseases/*diagnosis/pathology; Humans; Skin Diseases, Vesiculobullous/*diagnosis
{Abstract}: Autoimmune bullous dermatoses are a group of skin and/or mucous membrane diseases characterized by blisters and erosions, which are the results of autoantibodies directed to structural components of desmosomes and structural proteins of the basement membrane zone. In this group of diseases, the diagnosis is based on history, clinical presentation, histopathologic findings, findings of direct and   indirect immunofluorescence, and specific evidence of circulating antibodies by the enzyme linked immunosorbent assay (ELISA) method. Connective tissue diseases   are a heterogeneous group of diseases with some common pathogenetic mechanisms and frequent involvement of the skin. This group of diseases commonly includes lupus erythematosus, dermatomyositis/polymyositis, localized and systemic scleroderma. As most of the diseases in this group have positive one of the antinuclear antibodies, in clinical practice these diseases are often called autoimmune connective tissue diseases. In the group of autoimmune bullous dermatoses, wounds occur as the result of breaking of blisters, and consequently   affect the epidermis alone or epidermis and upper dermis, while in the group of systemic diseases of connective tissue, wounds occur in advanced stages of disease as a result of vascular tissue damage, causing necrosis of tissue and wounds. When wounds in these diseases last for a longer period (longer than 3 months), they are considered as chronic wounds and in these cases it is necessary to determine the reason for slow healing. In patients with wounds as a symptom of disease, besides systemic therapy, special attention should be paid to local therapy in order to prevent superinfection and accelerate epithelialization and wound healing.
{Notes}: Rane kod autoimunih buloznih dermatoza i sistemskih bolesti vezivnog tkiva.
{Author Address}: Zagreb University Hospital Center, University Department of Dermatovenereology, School of Medicine, University of Zagreb, Zagreb, Croatia.
{Language}: hrv

{Reference Type}: Journal Article
{Author}: Parente, J.; Mathurdas, P.; Wandschneider, L.; Aranha, J.; Siopa, L.
{Year}: 2011
{Title}: [Overlap syndrome]
{URL}: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=22856421&query_hl=1
{Tag}: 0
{Star}: 0
{Journal}: Acta Med Port
{Volume}: 24 Suppl 3
{Pages}: 719-24
{Date Displayed}: 2011 Dec
{Date}: 2011-12-01
{Type of Work}: Case Reports; English Abstract; Journal Article
{Accession Number}: 22856421
{Keywords}: Autoimmune Diseases/*pathology; Female; Humans; Middle Aged; Polymyositis/*pathology; Scleroderma, Localized/*pathology; Syndrome
{Abstract}: The overlap syndromes are characterized by the occurrence in the same patient of   two or more autoimmune diseases. The overlap syndrome between scleroderma and polymyositis is rare. We describe a case of a 58-year-old woman in which the clinical expression, the effect of therapy and the evolution, support the concept that this syndrome is a distinct clinical entity in the spectrum of autoimmune disease.
{Notes}: Sindroma de overlap.
{Author Address}: Servicos de Dermatologia e de Medicina Interna 2, Hospital Distrital de Santarem, Santarem, Portugal.
{Language}: por

{Reference Type}: Journal Article
{Author}: Pedersen, J. V.; Jensen, S.; Krarup-Hansen, A.; Riis, L.
{Year}: 2010
{Title}: Scleroderma induced by paclitaxel
{URL}: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20446892&query_hl=1
{Tag}: 0
{Star}: 0
{Journal}: Acta Oncol
{Volume}: 49
{Issue}: 6
{Pages}: 866-8
{DOI}: 10.3109/02841861003702510
{Date Displayed}: 2010 Aug
{Date}: 2010-08-01
{Type of Work}: Case Reports; Letter
{Accession Number}: 20446892
{Keywords}: Antineoplastic Agents, Phytogenic/administration & dosage/*adverse effects; Female; Genetic Predisposition to Disease; Humans; Middle Aged; Ovarian Neoplasms/*drug therapy/pathology; Paclitaxel/administration & dosage/*adverse effects; Peritoneal Neoplasms/*drug therapy/secondary; Scleroderma, Localized/*chemically induced/genetics; Sex Factors; Time Factors
{Language}: eng