{Reference Type}: Journal Article

{Author}: Dmitry V Kuklev；Abraham J Domb；Valery M Dembitsky

{Year}: 2013

{Title}: Bioactive acetylenic metabolites

{Tag}: 0

{Star}: 0

{Volume}: 20

{Issue}: 13

{Pages}: 114-115

{ISBN/ISSN}: 0944-7113

{Keywords}: Fungi；Antibacterial；Antitumor；Acetylenic metabolits；Polyacetylenes；Polyynes；Antifungal；Fatty alcohols；Acids；Cyclohexanoids；Carotenoids；Plants

{Abstract}:This article focuses on anticancer, and other biological activities of acetylenic metabolites obtained from plants and fungi. Acetylenic compounds belong to a class of molecules containing triple bond(s). Naturally occurring acetylenics are of particular interest since many of them display important biological activities and possess antitumor, antibacterial, antimicrobial, antifungal, and immunosuppressive properties. There are of great interest for medicine, pharmacology, medicinal chemistry, and pharmaceutical industries. This review presents structures and describes cytotoxic activities of more than 100 acetylenic metabolites, including fatty alcohols, ketones, and acids, acetylenic cyclohexanoids, spiroketal enol ethers, and carotenoids isolated from fungi and plants.

{Database Provider}: Web of Sciencedirect

{Language}: English

{Reference Type}: Journal Article

{Author}: Carla Pereira；Ricardo C Calhelha；Lillian Barros；Maria João R   P Queiroz；Isabel C F   R Ferreira

{Year}: 2014

{Title}: Synergisms in antioxidant and anti-hepatocellular carcinoma activities of artichoke, milk thistle and borututu syrups

{Tag}: 0

{Star}: 0

{Volume}:52

{Issue}: 0

{Pages}: 709-713

{ISBN/ISSN}: 0926-6690

{Keywords}: Synergism；Antioxidant activity；Medicinal plants；Syrups；HepG2

{Abstract}:Artichoke, borututu and milk thistle are three medicinal plants well-known for their capacity to prevent oxidative stress and many liver diseases. In a previous work, we reported the bioactivity of infusions and pills based on these plants; herein, the aim was to provide scientific information about the antioxidant and anti-hepatocellular carcinoma activities of syrups based on these medicinal plants and evaluate the synergism among the combined plants by using syrups based on the mixed plants or prepared form the combinations of individual species. The antioxidant activity was measured by radical scavenging activity, reducing power and lipid peroxidation inhibition, while the anti-hepatocellular carcinoma activity and the hepatotoxicity were evaluated using HepG2 human cell line and a primary culture of porcine liver cells, respectively. Milk thistle syrup proved to have the highest antioxidant activity in all the assayed methods, providing the best results either in single syrup or included in mixed syrups. Synergistic effects were the main interactions observed in the mixture of artichoke, borututu and milk thistle; mixing the syrups based on each single plant proved to be more efficient regarding antioxidant proposals than mixing plants in the same syrup. The latter was advantageous for anti-hepatocellular carcinoma activity.

{Database Provider}: Web of Sciencedirect

{Language}: English

{Reference Type}: Journal Article

{Author}: Lu Ren；Yacine Hemar；Conrad O Perera；Gillian Lewis；Geoffrey W Krissansen；Peter K Buchanan

{Year}: 2014

{Title}: Antibacterial and antioxidant activities of aqueous extracts of eight edible mushrooms

{Tag}: 0

{Star}: 0

{Volume}: 3

{Issue}: 2

{Pages}: 41-51

{ISBN/ISSN}: 2212-6198

{Keywords}: Antioxidant；Antibacterial；Mushroom polysaccharides；Disk diffusion；Microdilution；FT-IR

{Abstract}:Polysaccharides extracts of eight edible mushroom species, including five species collected from New Zealand forests and parks, were tested for their ability to inhibit the growth of five common bacterial strains. Antibacterial activity was assayed using the disc diffusion and microdilution methods. An aqueous extract from Cordyceps sinensis inhibited the growth of Bacillus subtilis and Streptococcus epidermidis with minimum inhibitory concentration (MIC) values of 938 and 469 μg/mL, respectively. A Pleurotus australis extract had the same MIC of 469 μg/mL against S. epidermidis. Comparatively, the microdilution method was more efficient and accurate than the disk diffusion method at measuring the antimicrobial activity of high molecular weight polysaccharides. All polysaccharides exhibited DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activities, with P. australis having the highest antioxidant activity (EC50 of 4.03 mg/mL). Fourier transform infrared (FT-IR) analyses indicated that some extracts contained α or β-conformations. Their relative quantities of OH, evaluated by the ratios of OH group/CH group, did not correlate with their scavenging activity based on EC50 values. Several of the mushroom polysaccharide extracts investigated in this study have antibacterial and antioxidant activities that warrant further study as potential dietary supplements to improve health and well-being.

ER-

{Database Provider}: Web of Sciencedirect

{Language}: English