{Reference Type}: Journal Article
{Author}: Yamaguchi, Yoshiyuki; Miyahara, Eiji; Hihara, Jun
{Year}: 2011
{Title}: Efficacy and Safety of Orally Administered Lentinula edodes Mycelia Extract for Patients Undergoing Cancer Chemotherapy: A Pilot Study
{Tag}: 0
{Star}: 0
{Journal}: AMERICAN JOURNAL OF CHINESE MEDICINE
{Volume}: 39
{Issue}: 3
{Pages}: 451-459
{ISBN/ISSN}: 0192-415X
{Keywords}: QUALITY-OF-LIFE; IMMUNOSUPPRESSIVE ACIDIC PROTEIN; ADVANCED BREAST-CANCER; GASTRIC-CANCER; CULTURE-MEDIUM; COMPLEMENTARY; MEDICINE; 5-FLUOROURACIL; EPIRUBICIN; JAPAN; Lentinula Edodes Mycelia; Cancer; Chemotherapy; Quality of Life; Immune Function
{Abstract}: Lentinula edodes mycelia extract (L. E. M.) is extensively utilized as an herbal medicine. However, its safety and effectiveness have not yet been scientifically verified. In this study, we investigated its safety and its influence on quality of life (QOL) and the immune response in patients undergoing cancer chemotherapy. Seven patients were studied in total. The patients were undergoing postoperative adjuvant chemotherapy for breast cancer (n = 3) or gastrointestinal cancer (n = 2), or were receiving chemotherapy to prevent recurrence of gastrointestinal cancer (n = 2). The first course of treatment was chemotherapy alone and the second was chemotherapy plus concomitant administration of L. E. M. Adverse events and changes in the QOL score, lymphocyte subpopulations, lymphocyte activity and serum immune indices were evaluated during the study period. No adverse events attributable to L. E. M. were observed. Compared to the pre-chemotherapy state, no changes in QOL or immune parameters were noted after the first chemotherapy course. In contrast, following the second course of combined therapy, improvements were noted in QOL (p < 0.05), NK cell activity (p < 0.05) and immunosuppressive acidic protein (IAP) (p < 0.01) levels. Although a future large-scale investigation is necessary to confirm these results, these data suggest that the concomitant of L. E. M. with chemotherapy is safe and improves the QOL and immune function of patients undergoing chemotherapy.
{Author Address}: Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Surg Oncol, Hiroshima 7348553, Japan; Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Surg Oncol, Hiroshima 7348553, Japan; Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Surg Oncol, Hiroshima 7348553, Japan
{Database Provider}: Web of Science SCI
{Language}: English
{Country}: Japan

{Reference Type}: Journal Article
{Author}: Zhou, Xiaoxia; Luo, Liping; Dressel, Waike; Shadier, Gulibahaer; Krumbiegel, Doreen; Schmidtke, Peter; Zepp, Fred; Meyer, Claudius U.
{Year}: 2008
{Title}: Cordycepin is an Immunoregulatory Active Ingredient of Cordyceps sinensis
{Tag}: 0
{Star}: 0
{Journal}: AMERICAN JOURNAL OF CHINESE MEDICINE
{Volume}: 36
{Issue}: 5
{Pages}: 967-980
{ISBN/ISSN}: 0192-415X
{Keywords}: HUMAN DENDRITIC CELLS; SCIENTIFIC REDISCOVERY; GENE-EXPRESSION; IN-VIVO; IL-10; DIFFERENTIATION; INHIBITION; MACROPHAGES; RECEPTORS; INDUCTION; Cordycepin; Cordyceps sinensis; Cytokines; Immune Regulation
{Abstract}: We have reported that cordycepin, an adenosine derivative from the fungus Cordyceps, increased interleukin (IL)-10 expression, decreased IL-2 expression and suppressed T lymphocyte activity. In the present study, we further characterized the regulatory effects of cordycepin on human immune cells. Moreover. a traditional Chinese drug, Cordyceps sinensis (CS) that contains cordycepin, was also investigated. Cytometric Bead Array (CBA) was used to determine the concentrations of IL-1 beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, TNF-alpha and IFN-gamma in Culture of peripheral blood mononuclear cells (PBMCs). The results showed that both cordycepin and CS Lip-regulated IL-10, IL-1 beta, IL-6, IL-8 and TNF-alpha; at the same time. they suppressed phytohemagglutinin (PHA)-induced production of IL-2, IL-4, IL-5, IFN-gamma and IL-12. As compared to cordycepin, CS displayed its regulatory effects on IL-2 and IL-10 in a similar dose-dependent manner even with higher efficiency. The binding activity of transcription factors in a human monocytic cell line THP-1 was tested by the trans-AM method, and a higher binding activity of SP1 and SP3 was observed in cordycepin or CS treated cells compared to the control. These results led to the opinion that cordycepin and CS pleiotropically affected the actions of immune cells and cytokine network in a similar fashion. Cordycepin could be an important immunoregulatory active ingredient in Cordyceps sinensis. In addition, CS may contain substances which possess synergism with cordycepin, as CS showed a higher efficiency in the production of IL-10 and IL-2 than cordycepin. However, merits of these effects in pharmacology and clinical medicine have yet to be proven and the precise mechanism of these immune regulatory actions should be researched.
{Author Address}: Johannes Gutenberg Univ Mainz, Childrens Hosp, Lab Paediat Immunol & Infect Dis, D-6500 Mainz, Germany; Johannes Gutenberg Univ Mainz, Childrens Hosp, Lab Paediat Immunol & Infect Dis, D-6500 Mainz, Germany; Johannes Gutenberg Univ Mainz, Childrens Hosp, Lab Paediat Immunol & Infect Dis, D-6500 Mainz, Germany; Johannes Gutenberg Univ Mainz, Childrens Hosp, Lab Paediat Immunol & Infect Dis, D-6500 Mainz, Germany; Johannes Gutenberg Univ Mainz, Childrens Hosp, Lab Paediat Immunol & Infect Dis, D-6500 Mainz, Germany; Johannes Gutenberg Univ Mainz, Childrens Hosp, Lab Paediat Immunol & Infect Dis, D-6500 Mainz, Germany; Johannes Gutenberg Univ Mainz, Childrens Hosp, Lab Paediat Immunol & Infect Dis, D-6500 Mainz, Germany; Johannes Gutenberg Univ Mainz, Childrens Hosp, Lab Paediat Immunol & Infect Dis, D-6500 Mainz, Germany
{Database Provider}: Web of Science SCI
{Language}: English
{Country}: Germany

{Reference Type}: Journal Article
{Author}: Shankar, Uday; Masood, Wajeed; Kasturi, Leelawathi; Bandagi, Sabiha
{Year}: 2010
{Title}: Overlap Syndrome of Autoimmune Hepatitis and Primary Biliary Cirrhosis in a Patient with Limited Scleroderma: Case Report and Review of Literature
{Tag}: 0
{Star}: 0
{Journal}: AMERICAN JOURNAL OF GASTROENTEROLOGY
{Volume}: 105
{Pages}: S303-S303
{ISBN/ISSN}: 0002-9270
{Author Address}: Queens Hosp Ctr, Mt Sinai Sch Med, Jamaica, NY USA; Queens Hosp Ctr, Mt Sinai Sch Med, Jamaica, NY USA; Queens Hosp Ctr, Mt Sinai Sch Med, Jamaica, NY USA; Queens Hosp Ctr, Mt Sinai Sch Med, Jamaica, NY USA
{Database Provider}: Web of Science SCI
{Language}: English
{Country}: USA

{Reference Type}: Journal Article
{Author}: Navarro, V.; Scott, C.; Briggs, T. A.; Barete, S.; Frances, C.; Lebon, P.; Maisonobe, T.; Rice, G. I.; Wouters, C. H.; Crow, Y. J.
{Year}: 2008
{Title}: Two Further Cases of Spondyloenchondrodysplasia (SPENCD) With Immune Dysregulation
{Tag}: 0
{Star}: 0
{Journal}: AMERICAN JOURNAL OF MEDICAL GENETICS PART A
{Volume}: 146A
{Issue}: 21
{Pages}: 2810-2815
{ISBN/ISSN}: 1552-4825
{Keywords}: AICARDI-GOUTIERES-SYNDROME; SYSTEMIC-LUPUS-ERYTHEMATOSUS; SPONDYLOMETAPHYSEAL DYSPLASIA; CONGENITAL INFECTION; IMMUNODEFICIENCY; CALCIFICATIONS; MICROANGIOPATHY; AUTOIMMUNITY; MUTATIONS; DISORDER; spondyloenchondrodysplasia; SPENCD; scleroderma; acrocyanosis; intracranial calcification; Aicardi-Goutieres syndrome; Sjogren syndrome; polymyositis; leukocytoclastic vasculitis; systemic lupus erythematosus
{Abstract}: Although the diagnosis of spondyloenchondrodysplasia (SPENCD) can only be made in the presence of characteristic metaphyseal and vertebral lesions, a recent report has highlighted the pleiotropic manifestations of this disorder which include significant neurological involvement and variable immune dysfunction. Here we present two patients, one of whom was born to consanguineous parents, further illustrating the remarkable clinical spectrum of this disease. Although both patients demonstrated intracranial calcification, they were discordant for the presence of mental retardation, spasticity and white matter abnormalities. And whilst one patient had features consistent with diagnoses of Sjogren syndrome, polymyositis, hypothyroidism and severe scleroderma, the other patient had clinical manifestations and an autoantibody profile of systemic lupus erythematosus. These cases further illustrate the association of SPENCD with immune dysregulation and highlight the differential diagnosis with Aicardi-Goutieres syndrome and other disorders associated with the presence of intracranial calcification. Undoubtedly, identification of the underlying molecular and pathological basis of SPENCD will provide important insights into immune and skeletal regulation. (c) 2008 Wiley-Liss, Inc.
{Author Address}: Hop La Pitie Salpetriere, Epilepsy Unit, AP HP, F-75651 Paris 13, France; Univ Hosp, Louvain, Belgium; St James Univ Hosp, York Reg Genet Serv, Leeds, W Yorkshire, England;
<AuCollectiveName>Barete, S.</AuCollectiveName>
</fullauthorname>
<author>Frances, C</author>
<fullauthorname>
<AuRole>Author</AuRole>
<AuLastName>Frances</AuLastName>
<AuFirstName>C.</AuFirstName>
<address number="4">Hop Tenon, APHP, Dept Dermatol &amp; Allergy, F-75970 Paris, France; Univ Paris 05, Paris, France; Hop Cochin St Vincent Paul, Serv Virol, Paris, France; Hop La Pitie Salpetriere, Federat Neurophysiol Clin, F-75651 Paris 13, France; Hop La Pitie Salpetriere, Lab Neuropathol R Escourolle, F-75651 Paris 13, France; St James Univ Hosp, Leeds Inst Mol Med, Leeds, W Yorkshire, England; Univ Hosp, Louvain, Belgium; St James Univ Hosp, Leeds Inst Mol Med, Leeds, W Yorkshire, England
{Database Provider}: Web of Science SCI
{Language}: English
{Country}: France; Belgium; England; France; France; France; France; France; England