{Reference Type}: Journal Article
{Author}: Ruthes, Andrea Caroline; Carbonero, Elaine R.; Cordova, Marina Machado; Baggio, Cristiane Hatsuko; Santos, Adair Roberto Soares; Sassaki, Guilherme Lanzi; Cipriani, Thales Ricardo; Gorin, Philip Albert James; Iacomini, Marcello
{Year}: 2013
{Title}: Lactarius rufus (13),(16)--d-glucans: Structure, antinociceptive and anti-inflammatory effects
{Tag}: 0
{Star}: 0
{Volume}: 94
{Issue}: 1
{Pages}: 129-136
{Date Displayed}: 2013
{ISBN/ISSN}: 01448617
{Keywords}: Polysaccharides; Alkylation; Formaldehyde; Fungi; Nuclear magnetic resonance spectroscopy
{Abstract}: Medicinal health benefits uses of edible as well as non-edible mushrooms have been long recognized. The pharmacological potential of mushrooms, especially antitumor, immunostimulatory and anti-inflammatory activities has been documented. Wild ectomycorrhizal mushroom, Lactarius rufus had the anti-inflammatory and antinociceptive potential of their polysaccharides evaluated using the formalin model. Two structurally different (13),(16)-linked -d-glucans were isolated from fruiting bodies. Soluble (FSHW) -d-glucan 1-30mgkg-1 produced potent inhibition of inflammatory pain caused by formalin when compared with the insoluble one (IHW), suggesting that solubility and/or branching degree could alter the activity of -glucans. Their structures were determined using mono- and bi-dimensional NMR spectroscopy, methylation analysis, and controlled Smith degradation. They were -d-glucans, with a main chain of (13)-linked Glcp residues, substituted at O-6 by single-unit Glcp side chains (IHW), on average to every fourth residue of the backbone, or by mono- and few oligosaccharide side chains for soluble -glucan.   2013 Elsevier Ltd.
{Notes}: Compilation and indexing terms, Copyright 2013 Elsevier Inc.
IP52463998
Anti-inflammatories
Anti-inflammatory activity
Anti-inflammatory effects
Antinociceptive
Anti-tumors
Branching degree
D-glucan
Ectomycorrhizal
Fruiting bodies
Glucans
Health benefits
Lactarius
Main chains
Methylation analysis
Potent inhibition
Side-chains
Smith degradation
{Author Address}: Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, CP 19046, CEP 81531-980, Curitiba, PR, Brazil

{Reference Type}: Journal Article
{Author}: Tong, Haibin; Liu, Ximing; Tian, Dan; Sun, Xin
{Year}: 2012
{Title}: Purification, chemical characterization and radical scavenging activities of alkali-extracted polysaccharide fractions isolated from the fruit bodies of Tricholoma matsutake
{Tag}: 0
{Star}: 0
{Pages}: 1-6
{Date Displayed}: 2012
{ISBN/ISSN}: 09593993
{Keywords}: Fruits; Oxygen
{Abstract}: Tricholoma matsutake, a high-class edible mushroom in China, has been regarded as famous foods and biopharmaceutical materials with a great deal of interest. In the previous investigations, researchers believe the water-soluble polysaccharide -glucan is the major active component of T. matsutake, which displays various biological activities. In the present study, two novel alkali-extracted polysaccharide fractions, TM-APS-1 and TM-APS-2, were isolated from the fruit bodies of T. matsutake by DEAE-cellulose and Sepharose CL-6B columns on ATKA explorer chromatography system. Their chemical and physical characteristics and radical scavenging capacity were valuated, including chemical methods, GC, HPLC, scavenging activity against DPPH radicals, superoxide radicals, hydroxyl radicals, and chelating ability. The results showed that TM-APS-1 and TM-APS-2 exhibited significantly antioxidant activity at a concentration-dependent manner. The alkali-extracted polysaccharide fractions from T. matsutake can be developed to be novel functional food or pharmaceutical products with antioxidant effects.   2012 Springer Science+Business Media Dordrecht.
{Notes}: Compilation and indexing terms, Copyright 2013 Elsevier Inc.
IP52354405
Active components
Antioxidant activities
Antioxidant effect
Chelating ability
Chemical and physical characteristics
Chemical characterization
Chemical method
Concentration-dependent
DEAE cellulose
Edible mushroom
Fruit body
Functional foods
Hydroxyl radicals
Pharmaceutical products
Radical scavenging
Radical scavenging activity
Scavenging activities
Superoxide radical
Water-soluble polysaccharides
{Author Address}: Life Science Research Center, Beihua University, Jilin, 132013, China

{Reference Type}: Journal Article
{Author}: Yan, Jing-Kun; Wang, Wen-Qiang; Li, Lin; Wu, Jian-Yong
{Year}: 2011
{Title}: Physiochemical properties and antitumor activities of two -glucans isolated from hot water and alkaline extracts of Cordyceps (Cs-HK1) fungal mycelia
{Tag}: 0
{Star}: 0
{Date Displayed}: 2011
{ISBN/ISSN}: 01448617
{Keywords}: Solvent extraction; Biodegradation; Cesium; Polydispersity; Polysaccharides; Water
{Abstract}: Two novel polysaccharides, WIPS and AIPS, were isolated and fractionated respectively from hot water and alkaline extracts of the mycelial biomass of a medicinal fungus Cordyceps sinensis (strain Cs-HK1). Through analytical and degradation experiments, WIPS and AIPS were characterized as -d-glucans with a backbone of (1   4)-linked -d-Glcp (60%) and very similar molecular weights (M w : WIPS 1180 kDa; AIPS 1150 kDa). WIPS had a short branch of (1   6)-linked -d-Glcp (14%), but AIPS was a linear glucan, distinctive from the branched structures of most glucans from medicinal fungi. In aqueous alkaline solutions, both AIPS and WIPS exhibited a random coil structure with the similar conformational parameters but significantly different polydispersity indexes, 0.19 versus 0.37. AIPS exhibited much more significant antitumor and immuno-stimulatory effects than WIPS in animal tests on melanoma tumor-bearing mice.   2011 Elsevier Ltd. All rights reserved.
{Notes}: Compilation and indexing terms, Copyright 2013 Elsevier Inc.
IP51388175
Animal tests
Anti-tumor activities
Anti-tumors
Aqueous alkaline solutions
Branched structures
Conformational parameters
Cordyceps sinensis
Glucans
Hot water
Medicinal fungus
Melanoma tumors
Mycelial biomass
Physio-chemical properties
Polydispersity indices
Random-coil structures
Stimulatory effects
{Author Address}: Department of Applied Biology and Chemical Technology, State Key Laboratory of Chinese Medicine and Molecular Pharmacology in Shenzhen, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong

{Reference Type}: Journal Article
{Author}: Hardin, Ian R.
{Year}: 2011
{Title}: The Organic Ties between Biology and Textile Chemistry: Fungi, Enzymes, and Green Chemistry
{Tag}: 0
{Star}: 0
{Journal}: AATCC REVIEW
{Volume}: 11
{Issue}: 3
{Pages}: 53-57
{ISBN/ISSN}: 1532-8813
{Keywords}: WHITE-ROT FUNGUS; PLEUROTUS-OSTREATUS; AZO DYES; MASS-SPECTROMETRY; COTTON FABRICS; PECTATE LYASE; BIODEGRADATION; DEGRADATION; HYDROLYSIS; CELLULASE
{Database Provider}: Web of Science SCI
{Language}: English
{Country}: USA