{Reference Type}: Book Section
{Author}: Wang, Hua-Pin; Liu, Ching-Wen; Chang, Hsueh-Wen; Tsai, Jen-Wei; Sung, Ya-Zhu; Chang, Li-Ching
{Year}: 2013
{Title}: Cordyceps sinensis protects against renal ischemia/reperfusion injury in rats
{Tag}: 0
{Star}: 0
{Volume}: 40
{Pages}: 2347-2355
{ISBN/ISSN}: 0301-4851
{Keywords}: ISCHEMIA-REPERFUSION INJURY; CELLS; KIDNEY; REPAIR; REGENERATION; MOBILIZATION; SENESCENCE; EXPRESSION; EXTRACT; Cordyceps sinensis; Kidney; Ischemia/reperfusion; SDF-1 alpha; CXCR4; Senescence
{Abstract}: Cordyceps sinensis (CS) is an entomogenous fungus used as a tonic food and Chinese medicine to replenish health. This study investigated the protective effects of CS in rats post-renal ischemia-reperfusion (I/R) sequence by analyzing the influence on stromal cell-derived factor-1 alpha (SDF-1 alpha and chemokine (C-X-C motif) receptor 4 (CXCR4) expressions and senescence during recovery. Chemokine SDF-1 [now called chemokine C-X-C motif ligand 12 (CXCL12)] and its receptor CXCR4 are crucial in kidney repair after ischemic acute renal failure. CS treatment significantly alleviated I/R-induced renal damage assessed by creatinine levels (p < 0.05) and abated renal tubular damages assessed by periodic acid-Schiff with diastase (PASD) staining. CS induced early SDF-1 alpha expression and increased CXCR4 expression 1-6 h post-reperfusion. Histology studies have revealed that CS induced SDF-1 alpha in squamous cells of Bowman's capsule, mesangial cells, distal convoluted tubules (DCT), and proximal convoluted tubules (PCT). CS also improved renal repair in I/R-induced injury by increasing Ki-67 staining. I/R induced renal senescence after 3 and 6 h of reperfusion. However, CS alleviated I/R-induced senescence at early stage (1 and 3 h). We conclude that CS protects against I/R injury via the SDF-1/CXCR4-signaling axis and alleviates senescence.
{Author Address}: I Shou Univ, Div Urol, E Da Hosp, Kaohsiung, Taiwan; Kaohsiung Med Univ, Sch Pharm, Kaohsiung, Taiwan; Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 80424, Taiwan; I Shou Univ, E Da Hosp, Dept Pathol, Kaohsiung, Taiwan; I Shou Univ, Div Urol, E Da Hosp, Kaohsiung, Taiwan; I Shou Univ, Dept Occupat Therapy, Kaohsiung, Taiwan
{Database Provider}: Web of Science SCI
{Language}: English
{Country}: Taiwan; Taiwan; Taiwan; Taiwan; Taiwan

{Reference Type}: Journal Article
{Author}: Luis Munoz-Munoz, Jose; Garcia-Molina, Francisco; Varon, Ramon; Tudela, Jose; Garcia-Canovas, Francisco; Rodriguez-Lopez, Jose N.
{Year}: 2011
{Title}: Kinetic cooperativity of tyrosinase. A general mechanism
{Tag}: 0
{Star}: 0
{Journal}: ACTA BIOCHIMICA POLONICA
{Volume}: 58
{Issue}: 3
{Pages}: 303-311
{ISBN/ISSN}: 0001-527X
{Keywords}: MELANIN BIOSYNTHESIS PATHWAY; MUSHROOM TYROSINASE; STEADY-STATE; MOLAR ABSORPTIVITIES; POLYPHENOL OXIDASE; AGARICUS-BISPORUS; MONOPHENOLASE; DIPHENOLASE; SUBSTRATE; DEHYDROGENASE; tyrosinase; o-diphenols
{Abstract}: Tyrosinase shows kinetic cooperativity in its action on o-diphenols, but not when it acts on monophenols, confirming that the slow step is the hydroxylation of monophenols to o-diphenols. This model can be generalised to a wide range of substrates; for example, type SA substrates, which give rise to a stable product as the o-quinone evolves by means of a first or pseudo first order reaction (a-methyl dopa, dopa methyl ester, dopamine, 3,4-dihydroxyphenylpropionic acid, 3,4-dihydroxyphenylacetic acid, a-methyl-tyrosine, tyrosine methyl ester, tyramine, 4-hydroxyphenylpropionic acid and 4-hydroxyphenylacetic acid), type 5, substrates, which include those whose o-quinone evolves with no clear stoichiometry (catechol, 4-methylcatechol, phenol and p-cresol) and, lastly, type 5, substrates, which give rise to stable o-quinones (4-tert-butylcatechol/4-tert-butylphenol).
{Author Address}: Univ Murcia, GENZ Grp Invest Enzimol, Dept Bioquim & Biol Mol A, Fac Biol, Murcia, Spain; Univ Murcia, GENZ Grp Invest Enzimol, Dept Bioquim & Biol Mol A, Fac Biol, Murcia, Spain; Univ Castilla La Mancha, Dept Quim Fis, Escuela Ingn Ind Albacete, Campus Univ, Albacete, Spain; Univ Murcia, GENZ Grp Invest Enzimol, Dept Bioquim & Biol Mol A, Fac Biol, Murcia, Spain; Univ Murcia, GENZ Grp Invest Enzimol, Dept Bioquim & Biol Mol A, Fac Biol, Murcia, Spain; Univ Murcia, GENZ Grp Invest Enzimol, Dept Bioquim & Biol Mol A, Fac Biol, Murcia, Spain
{Database Provider}: Web of Science SCI
{Language}: English
{Country}: Spain; Spain

{Reference Type}: Journal Article
{Author}: de Albuquerque, Margeli Pereira; Pereira, Antonio Batista; de Carvalho Junior, Anibal Alves
{Year}: 2010
{Title}: The family Agaricaceac Chevall. in the Tingua Biological Reserve rain forest, Nova lguack Rio de Janeiro, Brazil: Genera Agaricus. Cystolepiota and Lepiota
{Tag}: 0
{Star}: 0
{Journal}: ACTA BOTANICA BRASILICA
{Volume}: 24
{Issue}: 2
{Number}: WOS:000282913700020
{Pages}: 497-509
{Cited Count}: 0
{Date Displayed}: 2010
APR-JUN 2010
{ISBN/ISSN}: 0102-3306
{Abstract}: (The family Agaricaceae Chevall. in the Tingua Biological Reserve rain forest, Nova Iguacu Rio de Janeiro, Brazil: Genera Agaricus. Cystolepiota and Lepiota). Agaricaceae is the type family of Agaricales and its species are of nutritional and economic importance. The main aim of this survey was to describe the Agaricaccae species of rain forest patches in the Tingue Biological Reserve, located in the vicinity of Nova Iguack Rio de Janeiro state, Brazil. Species of the genera Agaricus. Cystolepiota and Lepiota, collected in different plant formations, are presented. The following taxa were recorded: Agaricus subrufescens Peck., A. dulcidulus Schulzer., Cystolepiota seminuda (Lasch) Bon, Lepiota. lilacea Bresadola., L. repeitensis Murril., L. forquignoni Quelet., L. echinela var rhodorhiza (Romagn. & Locq. ex. Orton) Hardtke & Rode! and L. subincarnata Lange. A species key, descriptions. habit photo, microscopic features, distribution and species importance (when known) are given.

{Reference Type}: Journal Article
{Author}: Huang, Chien-Hua; Tsai, Han-Ni; Peng, Ren-How; Hsieh, Yi-Hsuan; Chuang, Woei-Jer; Hsu, Ga-Ching; Huang, Wenya; Chen, Wen-Jone
{Year}: 2010
{Title}: Agaricus Blazei Murill Ameliorates Myocardial Ischemia-Reperfusion Injury
{Tag}: 0
{Star}: 0
{Journal}: ACTA CARDIOLOGICA SINICA
{Volume}: 26
{Issue}: 4
{Pages}: 235-241
{ISBN/ISSN}: 1011-6842
{Keywords}: IN-VITRO; ANTIOXIDANT ACTIVITY; GANODERMA-LUCIDUM; OXIDATIVE STRESS; GENE-EXPRESSION; HEART; INFARCTION; EXTRACT; MICE; MUSHROOM; Agaricus blazei Murill; Antioxidant; Ischemia-reperfusion; Myocardial infarction
{Abstract}: Background: Agaricus blazei Murill (ABM) is a widely accepted health food and is known to present anti-tumorigenic activities. ABM has also been reported to modulate oxidative stress after inflammation and infection. Reactive oxygen free radicals have been shown to be critically involved in ischemia-reperfusion injury cascades. We aimed to study the antioxidant activities of ABM against tissue injury caused by myocardial ischemia-reperfusion processes.
Methods: A rat cardiomyocyte H9c2 cell line was set up and used for the study. Cell viabilities after different dosages of ABM extract treatment and hydrogen peroxide injuries were checked. A cardiac ischemia-reperfusion injury model was set up to elucidate the cardioprotective roles of ABM extract. Different doses of 22.5 mg/kg of body weight and 45 mg/kg of body weight ABM extract were pre-treated at 24 and 48 hours before inducing the ischemia-reperfusion injury.
Results: ABM extract treatment increased the survival of cardiomyocytes without cytotoxicity. Pretreatment with ABM extract reduced hydrogen peroxide-induced cell damage and increased cell survival (0.86 +/- 0.15 in ABM 6.0 mg/ml vs. 0.45 +/- 0.03 in control, p = 0.019). ABM-pretreated rats that underwent myocardial ischemia-reperfusion had greatly reduced infarct areas compared to those in the control group (14.3 +/- 3.3% in control group, 4.6 +/- 1.9% in 22.5 mg/kg group, 4.9 +/- 2.1% in 45 mg/kg group, p < 0.05).
Conclusion: ABM increases antioxidant activity, which greatly ameliorates myocardial injuries caused by myocardial ischemia-reperfusion injuries. Using ABM as a health food may provide cardioprotective effect against ischemia-reperfusion injuries.
{Author Address}: Natl Taiwan Univ Hosp, Dept Emergency Med, Taipei 100, Taiwan; Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan;
<AuCollectiveName>Tsai, Han-Ni</AuCollectiveName>
</fullauthorname>
<author>Peng, RH</author>
<fullauthorname>
<AuRole>Author</AuRole>
<AuLastName>Peng</AuLastName>
<AuFirstName>Ren-How</AuFirstName>
<address number="1">Natl Taiwan Univ Hosp, Dept Emergency Med, Taipei 100, Taiwan;
<AuCollectiveName>Hsieh, Yi-Hsuan</AuCollectiveName>
</fullauthorname>
<author>Chuang, WJ</author>
<fullauthorname>
<AuRole>Author</AuRole>
<AuLastName>Chuang</AuLastName>
<AuFirstName>Woei-Jer</AuFirstName>
<address number="3">Natl Cheng Kung Univ, Coll Med, Tainan 70101, Taiwan; Simpson Biotechnol Inc, Tao Yuan, Taiwan; Natl Cheng Kung Univ, Coll Med, Tainan 70101, Taiwan; Natl Taiwan Univ Hosp, Dept Emergency Med, Taipei 100, Taiwan; Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan; Shin Chu Gen Hosp, Dept Internal Med, Shin Chu, Taiwan
{Database Provider}: Web of Science SCI
{Language}: English
{Country}: Taiwan; Taiwan; Taiwan; Taiwan; Taiwan